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LABORATORY
OF GLYCOBIOLOGY & PHYTOPHARMACOLOGY
Dr. P. REMANI,
M.Sc., Ph.D.
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Additional Professor
Division of Cancer Research
Regional Cancer Centre
Thiruvananthapuram – 695011
Kerala, India.
Phone : 91 471 2522337
Email
: remanipr@yahoo.com
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Brief overview of current
Research :
Medical world is still in search of an efficient
drug to cure cancer. Many plants are considered to possess
plenty of bioactive compounds with multiple biological properties
that can be further exploited for drug development. Therefore
there is need to study medicinal plants for their efficacy,
safety and quality, and also to search for potentially valuable
medicinal material from which novel curative agents may be
created for the benefit of the mankind. Search for novel agents
from plants with promising features of apoptosis induction
in cancer cells is an attractive strategy. This involves isolation
and characterization of the active component and evaluation
of apoptosis signaling induced by the compounds. Several antitumour
drugs are now known to induce apoptosis in cancerous cells
and thus cell apoptosis is considered to be a primary mechanism
against tumour cells.
The detection of phytochemical compounds,
for example, alkaloids, flavanoids, terpinoids, lectins, polysaccharides
with cytotoxic or anti-tumor activity could lead to the production
of new drugs for the treatment of cancer. One of the best
approaches in the search for anticancer agents from plant
resources is the selection of plants based on ethnomedical
leads and testing the selected plants efficacy and safety
in light of modern science. Our study aims to search and isolate
the physiologically active molecule or fraction from different
medicinal plants used in traditional systems of medicine practiced
in India and its bioactivity studies will pave way to the
discovery of a new non- toxic natural remedy.
Existing Projects
- Anticancer studies on selected Medicinal plants used
in Traditional and Folklore Medicine of Kerala.
- Ribosome Inactivating plant proteins as immunomodulating
and antitumour agents.
- Evaluation of Antitumour and Immunomodulating properties
of Elephantopus scaber. Linn.
- Detection and assessment of TF antigens in human malignant
tumours by plant lectins.
- Cytotoxic and Immunological evaluation of active principles
of two medicinal plants of Solanaceae.
Publications
- Expression of N acetyl D-galactosamine on leukemic cell
membranes. Remani, P., Rekha A Nair, Jaya, P., Bhattathiri,
V.N., Vijayakumar T and Nair M.K. Cell structure and function.
23: 88-90, 1998.
- Jack Fruit (Artocarpus integrifolia) lectin as a histochemical
marker for Ethmoid Carcinoma in Bovines. Manu Mohan S, Rajan.
A, Remani. P. Int. J. Anim. Sci. 13: 165-168, 1998.
- Relation of transmembrane potential to cell survival
following hyperthermia in HeLa cells. Remani P, Ostapenko
V.V, Akagi K, Bhattathiri V.N, Nair M.K, Tanaka Y. Cancer
Letters 144: 117-123, 1999.
- Altered expression of Jack fruit lectin specific glycoconjugates
in Benign and Malignant Human colorectum. Remani P, Rekha
a Nair, Sreelekha T. T, Jayaprakash Madhavan, Vijayakumar
T, Krishnan Nair M. J. Exptl. Clin. Cancer Research.19:
519-523, 2000.
- Lectin staining as a predictive test for radiosensitivity
of oral cancers. Remani P, Bhattathiri V. N, Bindu L, Krishnan
Nair M. International Congress Series, 1236: 463-466, 2002.
- Antitumour effect of Elephantopus scaber. Linn. Geetha
B. S, Latha P. G, Remani P. J. Tropical Medicinal Plants.
4: 75-79, 2003.
- Altered expression of Momordica charantia lectin specific
cell surface glycoconjugates in oral premalignant and malignant
lesions. Remani P, Smitha L. S, Laija S. Nair, Sujathan
K and Rekha A. Nair. Trends in Glycoscience and Glycotechnology.
16: 33-36, 2004.
- Antitumour constituents from Annona squamosa fruit pericarp.
Beena Joy and Remani P. Med Chem Res. 15: 121-122, 2007.
- Plant products as anticancer agents. Recent progress
in medicinal plants. Geetha B. S, Shyamal S, Latha P. G,
Remani P. Phytomedicines. 16: 323-338, 2007.
- Inhibitory effect of an extract from Curcuma zedoariae
on human cervical carcinoma cells. Lakshmi S, Dhanya G.
S, Beena Joy, Padmaja G, Remani P. Med Chem Res. 15: 176-178,
2007.
Ph. D. Students :
- Lashmi . S.
Email : lakshmi_deependran@yahoo.co.in
- Dhanya G. S.
Email : gsdhan@gmail.com
- Biba V. S.
Email : vsbiba@gmail.com
Alumni
Dr. K Sujathan sujathan@rcctvm.org
Dr. Laija S Nair laijamahesh@rediffmail.com
Dr. Smitha LS smithaniran@yahoo.com
Dr. Geetha LS geethadayal@rediffmail.com
Group
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