Caverject (Alprostadil auto-injectable) is a locally applicable medication used for the treatment of erectile dysfunction in adult men. It is administered directly into the cavernous bodies of the penis to maintain an erection for up to 60 minutes, so it deserves training and training by the doctor in its first uses. Consult everything you need to know before buying Caverject without a prescription: its mechanism of action, how it is administered, what special precautions should be taken, adverse effects that may occur, prices, and much more.
About Caverject: Caverject (Alprostadil) is an auto-injectable medication used for the treatment of male Erectile Dysfunction (ED), which acts directly on the corpora cavernosa of the penis.
What is Caverject? Caverject is the commercial name of the compound Alprostadil in presentation for intracavernous injection (administration of direct form in the penis). Alprostadil is a prostaglandin E1, a substance that produces vasodilation in the penis through different reactions that achieve a successful erection.
Administration: Administered through an injection directly into the corpora cavernosa of the penis, with a needle caliber between 27 to 30 and ½ inch in length. The training for its application at home must be previously explained in a careful way by trained health personnel, adjusting the dose to achieve satisfactory erections of no more than 60 minutes in duration.
Presentations available: There are two presentations currently on the market, Caverject Vials and Caverject double chamber in boxes containing 4 to 12 injections generally.
Caverject vials of 5 mcg, 10 mcg, 20 mcg and 40 mcg. (Contains a vial containing the active ingredient Alprostadil powder, a syringe containing the solvent, and two needles for preparation and administration, respectively.)
Caverject double chamber 10 mcg and 20 mcg. (Contains a pre-filled syringe ready to administer.)
Price per tablet: The price of Caverject varies according to the amount of injections contained in the box, the presentation available, and other factors such as whether to buy Caverject online and pay “dispensing fees” or buy Caverject at the pharmacy.
Online price of Caverject 5 mcg vials: prices ranging from € 52.28 to € 59.39 per injection, in boxes containing 1 to 4 injections.
Caverject online price 10 mcg vials: prices ranging from € 55.16 to € 64.65 per injection, in boxes containing 1 to 4 injections.
Caverject online price 20 mcg vials: prices ranging from € 62.93 to € 75.15 per injection, in boxes containing 1 to 4 injections.
Caverject online price 40 mcg vials: prices ranging from € 77.28 to € 95.75. in boxes containing 1 to 4 injections.
Online price of Caverject double chamber 10 mcg: prices ranging from € 25, 40 to € 37.57 per injection, in boxes containing 2 to 12 injections.
Caverject double chamber 20 mcg online price: prices ranging from € 31.47 to € 42.69 per injection, in boxes containing 2 to 12 injections.
Beginning of action: As it is a medication administered directly to the penis, its beginning of action does not exceed 5 minutes if the dose has been previously adjusted and is adequate.
Duration of action: If the dose is adequate, the erection to maintain satisfactory sexual intercourse should not exceed 60 minutes after administration of Caverject.
Alteration with meals: Due to local action, no interactions between food consumption and Caverject administration have been reported.
Side effects: The most frequently reported adverse reaction to the use of Caverject is penile pain, which decreases with improved technique and passage of time. Other less frequent adverse effects that may occur with this medication are: hematoma or ecchymosis at the injection site, muscle spasms, increased, prolonged or painful erection, Peyronie’s disease, headache, dizziness, pain or bleeding from the urethra, skin rash, itching or redness of the penis, pain or itching of the genital area in general, inflammation or edema of the penis, balanitis, tingling or pulsation sensation in the penis, numbness of the penis, gastrointestinal hemorrhage.
How does Caverject work?
Alprostadil, the active principle of Caverject, is a prostaglandin E1. Prostaglandin E1 is a substance administered directly to the corpora cavernosa which inhibits the vasoconstrictive activity of the penis, causing the smooth muscle to relax and more blood to flow to the penis producing an erection.
Why switch to Caverject?
Being the only molecule authorized by the FDA to be injected by the patient himself into the penis, Alprostadil proves with its efficacy and safety to be a reliable alternative in the treatment of erectile dysfunction. Patients who have tried other methods without satisfactory results or have contraindications, find in Caverject a cost-effective and direct option, without interaction with drugs or alcohol, and without the need for prior sexual stimulation to achieve an erection.
How to use and dosage of Caverject:
The way Caverject is administered must be explained by a health professional before it can be used at home and self-injected by the patient.
The first step is the preparation of the medication: if you have purchased Caverject in vials, you must use the larger caliber needle to insert the solvent into the vial containing Alprostadil powder, and shake until it is properly diluted. Once it is well mixed, aspirate it again with the large calibre needle. To administer, carefully change the needle to the smaller size (usually labeled 27 to 30).
Caverject should be administered directly to the corpora cavernosa of the penis, with one on each side of the stem. After being naked and in a comfortable position, use an alcohol wipe to clean the area to be injected. Then, hold the penis with your thumb and forefinger forming a “bulging” area to inject into the corpora cavernosa, avoiding visible veins or blood vessels. At a 90-degree right angle, insert the needle and gently push the fluid in. If you notice any resistance, move the needle or move it slightly. Massage the penis so that the medication is well distributed, and within 5 to 10 minutes, there should be an erection.
The dose of Caverject should be individualized for each case. Usually, the dose adjustment is made from 2.5 mcg by the doctor, until a satisfactory erection is achieved, and can be increased if there is no response of 5 to 10 minutes; or decreased if the erection is prolonged for more than one hour, which is highly discouraged.
The use of a single injection of Caverject per day is recommended, and no more than two to three injections per week. Each injection should be separated from the previous injection for at least 24 hours.
Isaverject effective every time it is used?
Because it is a medication that acts directly on the penis, Caverject is usually quite effective if used with the right dose for each case. Of course, the tolerability and demand of each organism is different, and multiple factors can influence its effectiveness.
Undesirable effects that may occur with Caverject:
The most frequently reported side effect is penile pain.
Less frequently, adverse reactions have occurred such as hematoma and redness at the injection site; cramps and tingling in the penis; scarring and angulation in the penis (disorders such as fibrosis, angulation, fibrotic nodules, Peyronie’s disease), prolonged erection.
Some rare but more serious adverse effects to general health may occur with caverject: fungal infection, common cold symptoms, decreased awareness and sense of touch, exaggerated sensation of stimuli, sensitivity to light, increased heart rate, hypotension, circulatory disorders, nausea, dry mouth, rash, increased sweating, itching of the penis, blood in the urine, priapism (prolonged erection for more than six hours), pelvic pain, swelling and pain in testicles, headache, hypertension, back and limb pain, stroke.
Contraindications: Cases in which Caverject should not be administered.
- Hypersensitivity to Alprostadil or any of the components of the formula.
- Women and children.
- History that may predispose to the appearance of priapism (erection that lasts for more than six hours), such as sickle cell anemia, multiple myeloma or leukemia, sickle cell anemia, thrombocytopenia, polycythemia, propensity to venous thrombosis or hyperviscosity syndrome.
- Anatomical deformity of the penis, such as angulation, cavernous fibrosis or Peyronie’s disease.
- Penile implant.
- Patients for whom sexual activity is not recommended or contraindicated due to cardiovascular or cerebrovascular disorders.
Interactions of the drug Caverject with other substances:
The effect of Caverject may be decreased by concomitant use with sympathomimetics, decongestants and appetite suppressants.
It may increase the effects of antihypertensives, vasodilators, anticoagulants (such as warfarin, heparin, increasing the risk of bleeding), and platelet aggregation inhibitors.
Caverject should not be used at the same time as other drugs for erectile dysfunction.
Fertility, Pregnancy, and Breastfeeding
It is not indicated for use in women, so it has not been studied on pregnancy and lactation. Fertility conditions have not been demonstrated.
With administrations higher than recommended, no overdose was observed in clinical trials with Alprostadil. However, systemic effects common to prostaglandin E1 toxicity could occur. If this is the case, you should contact the emergency department immediately for treatment of each systemic symptom and monitoring until it is resolved.
In case of prolonged erection due to overdose, the patient should remain in the medical service until detumescence of the penis occurs.
FAQ (Frequently Asked Questions):
Why should patients consult a doctor before using erectile dysfunction medications for the first time?
With Caverject it is especially important to consult the doctor before starting to use it, as training for its proper administration should be by health professionals until they consider that the patient is ready to do it by himself.
What is the difference between Caverject and Viagra?
There are many differences between Caverject (Alprostadil) and Viagra (Sildenafil), among them: its compounds are different, Alprostadil is a prostaglandin with direct vasodilator action, while Sildenafil is an inhibitor of phosphodiesterase 5; Caverject is injected directly into the penis, while Viagra is taken orally; Caverject has a 5 to 10 minute onset of action with the proper dose and produces erections that should not last longer than 60 minutes, while Viagra starts its action 25 to 30 minutes after taking and lasts 4 to 6 hours.
Is Caverject stronger than Viagra?
Despite being completely different medications, its effectiveness is relatively similar, so one cannot speak of one being stronger than the other. What is proven is that Caverject produces erections 5 to 10 minutes after the injection and does not need sexual stimulation to work, while Viagra needs the previous stimuli and takes longer to produce its effect.
What is the recommended dose to start using Caverject?
The dose of Caverject should be individualized for each patient by the doctor, but the initial dose is usually the lowest possible. either by vials or double chamber. The dose can be gradually increased from the lowest by the health personnel if no suitable results are given, or decreased if erections of more than 60 minutes are produced, which is not recommended.
Is there a generic?
Caverject in the form of Alprostadil for intracavernous injection does not have a generic currently available on the market.
Why does the price vary so much?
Laboratories sell the drug to pharmacies at a general standard price, but when it is received by pharmacists, they are free to set the retail price at their convenience.
In addition, depending on whether you are going to buy Caverject online or buy Caverject price in pharmacy, costs vary by factors inherent to each situation.
How long does the Caverject effect last, and how often can I take it?
Caverject is administered for a recommended duration of action of approximately 60 minutes.
Cheap Caverject can be used only once a day, and its maximum use is recommended two to three times a week, with 24 hours separation between each administration.
Can I drink alcohol if I am using Caverject?
Yes, you can drink alcohol safely while using Caverject.
Can I use Caverject with other medications?
Caverject has some interactions with other medications, so you should consult your doctor to find out if these will be affected according to each patient’s history.
Caverject should not be used at the same time as other treatments for erectile dysfunction, as it increases the risk of prolonged erections or serious adverse effects.
Can Caverject produce unwanted erections?
Since cheap Caverject only acts after direct administration and for a limited period of time, it does not produce spontaneous erections once the effect has worn off.
Do I need a prescription to buy Caverject, or can I buy it without one?
Because it is a drug that deserves training and training to perform self-injection, you need a medical formula to buy Caverject at a pharmacy price.
However, with the new modalities for purchasing Caverject online, if you have previously used the drug and are able to do so on your own, you can purchase Caverject online without a prescription, following the digitized medical evaluation of trusted sites and authorized to sell it.
Is caverject less expensive online than in the pharmacy?
Prices can vary significantly between buying Caverject online or buying Caverject at the pharmacy, especially if you take into account shipping costs, medical consultation costs to get the prescription, and others. Sometimes it can be less expensive to buy Caverject online than if you count travel and other expenses to go to the pharmacy.
What should I do if Caverject doesn’t work or becomes ineffective over time?
Because Caverject is a medication that is administered in a specialized way and the dose is adjusted individually, if Caverject is not producing the desired effect, the doctor should be consulted so that he can decide how to proceed.