Vardenafil (Levitra, trade name) is a drug used for male sexual disorders in general, specifically for erectile dysfunction. Below important information such as its presentation, price, mechanism of action, effectiveness, side effects and everything you need to know before you start taking it.
About Levitra: Levitra is the trade name for Vardenafil, a compound used in Erectile Dysfunction (ED).
How is it presented? It is found in film-coated oral tablets and as oral-dispersible tablets. Tablets of 5, 10mg and 20mg in boxes ranging from 10 to 360 tablets.
Price per tablet: The price per tablet varies depending on the box with the amount of tablets purchased.
Levitra 5 mg: prices ranging from € 0.69 to € 1.75 per tablet.
Levitra 10 mg: prices ranging from € 1.02 to € 1.82 per tablet
Levitra 20 mg: prices ranging from € 1.46 to € 2.98 per tablet
Method of administration: Oral. Film-coated tablets should be taken with a glass of water, 25 to 60 minutes before intercourse; the oral-dispersible tablet is consumed without water approximately 60 minutes before intercourse.
Dosage: Based on its efficacy, the dose may be increased or decreased upon patient demand and tolerability from 10 mg (recommended initial dose) to 5 mg or 20 mg.
The recommended dose is once a day.
Duration of action: The average duration of the effect of Levitra is approximately 4 to 6 hours.
Meal Administration: Food intake is not contraindicated, but high-fat meals may delay the onset of pharmacological activity. It should not be taken with grapefruit juice.
Side effects: Generally well tolerated, however some adverse reactions that may occur are headache, facial redness, dizziness, nasal congestion and dyspepsia.
Some very rare but more serious adverse effects include severe hypotension, priapism, glaucoma, and cardiovascular events.
How does Levitra work?
Its main mechanism of action is through a complex cascade of actions that produces an increase in blood flow to the penis with sexual stimulation.
Technically, Levitra is a potent and selective inhibitor of phosphodiesterase type 5 (PDE5), which is the enzyme most responsible for degrading Cyclic Guanosine Monophosphate (cGMP) in the corpora cavernosa of the penis, whose function is to mediate the relaxation of this smooth muscle and promote greater blood flow to the penis. Through the inhibition of this enzyme, Levitra increases blood circulation and allows erection.
Why use Levitra?
Levitra is an excellent and improved option for adult men with erectile dysfunction, as it has a faster onset of action, an affordable price and presentation that varies the options so that it is the patient who chooses between coated and bucodispersible tablets (which should only be placed in the mouth, to be diluted).
Considering that male sexual performance disorders affect between 30 and 52% of men between the ages of 40 and 70 in Spain, it is more than necessary to consider the use of more effective medications, at a lower cost, and with a greater margin of safety, such as Levitra.
How to use and dosage of Levitra
Levitra must be taken 25 to 60 minutes before sexual intercourse to be effective.
The recommended initial dose of Levitra is one 10 mg tablet, once a day. Depending on patient demand and tolerability, it may be decreased to 5 mg or increased to 20 mg.
The maximum recommended dose of Levitra is 20mg once a day.
Is Levitra effective every time it is used?
Levitra’s effectiveness rate is one of the highest available on the market, with a 65 to 80% success rate of penetration after taking compared to placebo.
Undesirable effects that may occur with Levitra
Side effects that have been reported with the use of Levitra are headache, dizziness, facial redness, nasal congestion, and dyspepsia.
Rarer adverse reactions that have occurred include allergy, sleep disturbances, visual disturbances, myocardial infarction and other cardiovascular events, hypotension and hypertension, abdominal pain, gastroesophageal reflux, nausea, diarrhea, rash, muscle aches, and priapism (painful erection).
- Hypersensitivity to any of the components of the formula.
- Concomitant use with nitrates or nitric oxide liberators.
- Severe liver failure.
- End-stage renal failure requiring dialysis.
- Hypotension (Blood pressure less than 90/50 mmHg)
- Patients who have lost vision in one eye due to non-arteritic anterior ischemic neuropathy, regardless of whether or not this episode was related to taking a PDE inhibitor5).
- Unstable angina pectoris, or severe heart failure.
- Recent history of cerebrovascular disease or myocardial infarction (within the past 6 months).
- Inherited degenerative diseases of the retina, such as retinitis pigmentosa.
- Concomitant use with potent inhibitors of CYP34A ketoconazole and itraconazole in men over 75 years of age.
- Concomitant use with HIV protease inhibitors such as ritonavir and indinavir.
- Concomitant use with stimulators of Guanylase Cyclase, such as riociguat, as it may produce symptomatic hypotension.
Interactions of Levitra with other drugs:
- Inhibitors of liver enzymes, or that are processed through them, can decrease their clearance and increase their concentration in blood.
- Its concomitant administration with indinavir and ritonavir (HIV protease inhibitors), ketoconazole or itraconazole (antifungals), erythromycin (an antibiotic) alters plasma concentrations of Levitra and is not recommended.
- Administered at the same time as other nitrates and nitric oxide enhancers can potentially produce hypotension.
- In patients treated with alpha-blockers it can produce symptomatic hypotension.
- Used concomitantly with Riociguat (treatment for pulmonary hypertension), it produces a marked drop in blood pressure.
Fertility, Pregnancy and Breastfeeding
Levitra has no indications for use in women, and no studies have been done in pregnant women. No data are available on its effects on fertility.
According to studies, up to 80 mg of Levitra per day are tolerated without serious adverse effects. With higher doses, intense back pain may occasionally occur.
If an overdose occurs from taking higher than safe doses, normal supportive measures should be offered.
FAQ (Frequently Asked Questions):
Why should patients consult a doctor before starting treatment for erectile dysfunction for the first time?
Medications to treat erectile dysfunction, such as Levitra, have certain contraindications, warnings, and risks that are best known to medical professionals. Although it is fairly safe, not all patients are fit to consume it, based on their personal medical history and history, and it is the physician who can determine if it is safe to start treatment.
In addition to this, it is a physician who can best explain the manner of administration, recommended dosage, possible adverse effects, and other details of Levitra that should be known to the patient.
What is the difference between Levitra and Viagra?
Although Levitra and Viagra share some similarities in the way they act in the body, they have certain differences, among them the most important are the doses in which they occur, the name of their components (Levitra is Vardenafil, and Viagra, Sildenafil), and the frequency of their adverse reactions (with Viagra there is a greater likelihood of nosebleeds, hearing loss, and cardiovascular events).
Is Cialis stronger than Levitra?
The way of administration, active principles and side effects of Levitra and Cialis are similar because they belong to the same group of drugs: one cannot be said to be stronger than the other. However, Cialis has an effect duration of up to 36 hours, while that of Levitra is slightly less and allows greater flexibility to take it only when needed.
What is the recommended dose to start taking Levitra?
The recommended dose for starting treatment with Levitra is usually its average presentation of 10 mg, and depending on whether it works well for the patient with this dose and whether it is well tolerated by the patient, it can be reduced to 5 mg or increased to 20 mg.
Is there a generic for Levitra?
Generic Levitra is the only one currently available from your laboratory, Bayer, and its price has proven to be quite affordable compared to others.
Why is the price so variable?
The laboratory that produces Levitra (Bayer) sets the prices at which they are sold to pharmacies. However, once they purchase the product for sale, they are free to offer them at the price they choose. This is why there are so many differences in price between pharmacies.
With the possibility of buying Levitra online, higher prices have also been presented in some places, but it saves the patient the need to go to the doctor to formulate the medicine.
How long does the Levitra effect last, and how often can it be taken?
The effect of Levitra lasts from 4 to 6 hours after taking it.
The recommended dose is one tablet per day.
The maximum recommended daily safety dosage is one tablet of 20 mg per day.
Can alcohol be taken by taking Levitra?
In general, it is safe to take alcohol in low amounts if you take Levitra and its effect is not altered. However, alcohol itself can worsen erectile dysfunction, so medications to treat it may not work as effectively.
Can Levitra be taken with other medications?
Levitra is generally safe; however, it has specific interactions with other medications and it is up to the doctor to confirm if it is safe to take along with other treatments.
Can Levitra cause unwanted erections?
Levitra only works with sexual stimulation, and does not cause unwanted erections after taking it without it.
Can the Levitra tablet be broken so as not to be taken whole?
Levitra is a coated tablet, so in addition to the fact that it can be difficult to split in half exactly, it is not recommended to do this with any treatment as the dosage can be altered.
Do I need a prescription to buy Levitra or can it be purchased without it?
Since Levitra is a medicine that must be prescribed by a doctor before starting treatment, pharmacies request a prescription to sell it.
Is Levitra cheaper online than in presential pharmacies?
In general, Levitra purchased online may be less expensive than in in-person pharmacies. However, the most important thing is to make sure that it is a reliable and authorized site to sell Levitra.
What to do if Levitra does not work or becomes ineffective over time?
If, at maximum doses, Levitra does not work for a patient, it is ideal to consult with the doctor to learn about other available options. Never self-medicate, or take more than the maximum suggested dose.