Buy Spedra online without prescription and at what price?

Spedra (Avanafil) is a new drug indicated for the treatment of male erectile dysfunction, the most innovative and best tolerated in the group of phosphodiesterase 5 inhibitors (along with Sildenafil or Viagra, Tadalafil or Cialis, and Vardenafil or Levitra). Before starting treatment with Spedra to improve your sexual performance consult here its mechanism of action, presentation in which you will find it, expected adverse reactions, in which cases you should not take it, how to take it, prices at which you can get it, if you need a prescription to acquire it, and all the important information you need to know.

About Spedra: Spedra (Avanafilo) is an innovative drug, licensed for sale in the United States and Europe since 2014, used to treat Erectile Dysfunction (ED) in adult men.

What is Spedra? Spedra is the trade name of the compound Avanafil, a highly selective inhibitor of phosphodiesterase 5 (PDE5), which is indicated for the treatment of disorders of male sexual function, especially erectile dysfunction. It belongs to the group with the mechanism of action of the active principles of Levitra, Cialis and Viagra.

Lab: Menarini Laboratories (Menarini Group)

Method of administration: One tablet should be taken orally, with water, 15 to 30 minutes before beginning sexual activity. It can be taken with or without food. This medicine is only effective under sexual stimulation.

Presentations available: film-coated oral tablets of 50 mg, 100 mg, and 200 mg, in boxes containing 10 to 120 tablets.

Price per tablet: The price of Spedra per tablet may vary depending on the amount of tablets in the box, whether Spedra is purchased online or if Spedra is purchased in pharmacy.

Price of cheap Spedra 50 mg: prices ranging from € 3.48 to € 4.12 per tablet.
Price of cheap Spedra 100 mg: prices ranging from € 3, 75 to € 4.58 per tablet.
Price of cheap Spedra 200 mg: prices ranging from € 4.15 to € 5.23 per tablet.

Start of action: It is recommended that Spedra be taken 15 to 30 minutes before beginning sexual activity to present its effect. There are reported cases in which the dose of 50 mg reaches its maximum effect 30 to 45 minutes after taking, and the dose of 100 mg to 200 mg 15 to 30 minutes after taking. Spedra (Avanafil) is currently the only PDE5 inhibitor approved for use 15 minutes before sexual intercourse, making it the fastest acting onset.

Duration of action: The duration of Spedra’s effect on the body is 4 to 6 hours. Exceptional cases of mild to moderate erectile dysfunction have been reported in which the effects after ingestion have been prolonged from 8 to 12 hours.

Alterations with food: Spedra can be taken with or without food, but it must be taken into account that sometimes when ingested with food its effect may take longer to start, although these are exceptional cases. Grapefruit juice should not be taken for 24 hours before ingesting Spedra.

Side Effects: Although Spedra is generally very well tolerated, some adverse reactions that may occur are headache, facial redness, nasal congestion and abdominal discomfort.

Other adverse effects that have rarely been reported, but may be more severe, are allergic rhinitis, dizziness, drowsiness, insomnia, premature ejaculation, tachycardia, angina pectoris, blurred vision, hypertension, nosebleeds, rash, muscle aches, edema, or swelling in face and body.

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How does Spedra work?

Phosphodiesterase 5 (PDE5) is an enzyme responsible for regulating the presence of the substance called Guanosine Cyclic Monophosphate (cGMP), a mediator that allows dilation and blood flow to the penis during sexual arousal to achieve an erection. Avanafil, Spedra’s active ingredient, inhibits PDE5 in order to increase the presence of cGMP and, with it, blood flow to the spongy tissue of the penis under sexual stimulation, achieving a satisfactory erection.

Why switch to Spedra?

Spedra is the newest PDE5 inhibitor drug for the treatment of erectile dysfunction in adult men, and has an improved formula. Compared to the other drugs in its group, it has higher phosphodiesterase 5 selectivity (fewer side effects), faster onset of action (as little as 15 minutes), and high effectiveness with excellent patient tolerance.

Instructions for use and dosage of the medicine Spedra

The recommended initial dose of Spedra is one 100 mg tablet (average presentation) per day, 15 to 30 minutes before sexual activity begins. Depending on its efficacy and tolerability on the part of the patient, the dose may be decreased to 50 mg or increased to its maximum presentation of 200 mg.

The maximum dose that can be consumed per day is its maximum presentation of 200 mg.

Is Spedra effective every time it is taken?

Although it is a newly launched drug compared to other PDE5 inhibitors, Spedra has a sexual encounter rate with successful penetration after taking more than 70%, making it quite effective and safe.

Undesirable effects that might occur with taking Spedra

Spedra has a high safety profile and is usually well tolerated. The most common adverse effects are headache, nasal congestion, facial redness and back pain.

To better understand all the adverse effects that have been reported with Spedra, they can be divided into frequent, infrequent and rare.

  • Frequent (1 case per 10 to 100 patients): headache, facial redness, nasal congestion.
  • Infrequent (more than 1 case per 100 to 1,000 patients): dizziness, drowsiness, sinus headache, blurred vision, palpitations, dyspnea, dyspepsia, nausea, vomiting, abdominal discomfort, back pain, fatigue, elevation of liver enzymes, abnormal electrocardiogram, tachycardia.
  • Rare or very rare (more than 1 case per thousand to ten thousand patients): rhinopharyngitis, allergic rhinitis, gout, insomnia, premature ejaculation, inappropriate affection, psychomotor hyperactivity, angina pectoris, hypertension, nosebleeds, dry mouth, gastritis, diarrhea, skin rash, muscle pains and spasms, frequent need to urinate, weakness, chest pain, swelling of limbs, weight gain, increase in body temperature.

Contraindications (cases in which you should not take Spedra):

  • Patients with hypersensitivity to the active ingredient or any of the excipients contained in the formula.
  • Patients in concomitant use with nitrates.
  • Joint treatment with a medicine called Riociguat, as it can produce symptomatic hypotension.
  • History of myocardial infarction, cerebrovascular disease or serious arrhythmias in the last 6 months.
  • Patients with hypotension at rest (blood pressure less than 90/50 mmHg) or uncontrolled hypertension (blood pressure greater than 170/100 mmHg).
  • History of unstable angina, angina triggered by sexual activity, or class II or greater congestive heart failure.
  • Patients with severe liver or kidney failure.
  • History of vision loss in one eye by non-arteritic anterior ischemic optic neuropathy, whether or not related to intake of PDE5 inhibitors.
  • Patients with hereditary degenerative disorders of the retina.
  • Concomitant use with potent CYP3A4 inhibitors (such as ketoconazole, itraconazole, ritonavir, atazanavir, indinavir, nelfinavir, saquinavir, clarithromycin, telithromycin, or nefazodone).
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Interactions of Spedra with other substances or drugs:

There are other drugs that, when used together with Spedra, can increase or reduce its plasma concentration and effects, or Spedra can do the same on them. In these cases, the doctor with the medical history is the one who must evaluate the risk-benefit. These medications are:

  • Medications for high blood pressure.
  • Alpha-blockers.
  • Other PDE5 inhibitors or drugs to treat erectile dysfunction.
  • CYP3A4 inhibitors (ketoconazole, itraconazole, voriconazole, clarithromycin, erythromycin, nefazodone, saquinavir, nelfinavir, indinavir, atazanavir, and telithromycin).
  • Grapefruit juice.
  • Cytochrome P450 inducers (rifampicin, carbamazepine, phenobarbital, efavirenz).

Fertility, Pregnancy and Breastfeeding

In studies of individuals with mild to moderate erectile dysfunction, no negative effects on fertility or changes in sperm count associated with Spedra intake were recorded.

Since Spedra is not indicated in women, its effects on pregnancy or lactation have not been studied.


In studies conducted to evaluate the safety of Spedra, the same adverse reactions were reported as with lower doses but with greater severity with the taking of 800 mg of medication in healthy individuals.

In case of overdose, take the usual supportive measures and call the emergency number.

FAQ (Frequently Asked Questions):

Why should patients consult a doctor before starting treatment for erectile dysfunction for the first time?

Drugs to treat erectile dysfunction, especially the group of PDE5 inhibitors such as cheap Spedra, have numerous contraindications and specifications that are best known to the doctor. In addition to this, the proper dosage, method of administration and other conditions to be able to start treatment must be appropriate to the case of each particular patient.

What is the difference between Spedra and Viagra?

Although Spedra (Avanafil) and Viagra (Sildenafil) share the mechanism of action and belong to the same group of PDE5 inhibitor drugs, they have some fundamental differences.

Spedra has a faster onset of action (15 minutes) than Viagra (it is suggested that it be taken even 60 minutes before sexual activity). In addition, the consumption of food and alcohol can delay the absorption of Viagra, while it has no significant effects on Spedra.

Is Spedra stronger than Viagra?

In terms of effectiveness and potency, they are similar and cannot be talked about one above the other. However, Spedra (Avanafil) does have a faster onset of action than Viagra (Sildenafil).

What is the recommended dose to start Spedra?

The recommended initial dose to start taking Spedra is its average presentation of 100 mg. This can be reduced to its 50 mg presentation or increased to its 200 mg presentation, depending on whether the desired effect has been achieved and how the patient has tolerated it.

Is there a generic for Spedra?

Since Spedra is a new drug for the treatment of erectile dysfunction, there is no generic at present.

Why does the price vary so much?

Initially, it is the laboratory that sets the prices to get it to pharmacies. After it is purchased for sale, it is the pharmacies that decide the final retail price, and this varies considerably the price of Spedra in pharmacy depending on the establishment.

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In addition, currently with the possibility of buying cheap Spedra online, the price can vary by shipping costs, not having to go to the doctor for a prescription, and other distribution factors.

How long does the Spedra effect last, and how often can I take it?

The Spedra effect lasts in the body for 4 to 6 hours, but it is not recommended to take more than one tablet once a day.

The maximum frequency at which it can be taken is one tablet of its highest presentation, once a day.

Can I drink alcohol if I am taking Spedra?

It has not been proven that there are significant interactions between the intake of Spedra and the consumption of alcohol therefore, it is not contraindicated. However, a lower risk of hypotension with mass consumption has been reported.

In addition, alcohol can cause a delay in getting an erection due to drug-independent effects.

Can I take Spedra with other medications?

Spedra, like the other PDE5 inhibitors, has numerous interactions with other drugs, so before starting it you should consult your doctor if it is safe to take it with existing treatments.

Spedra should not be taken at the same time as other treatments for erectile dysfunction, or other PDE5 inhibitors. The effect is not potentiated and may lead to serious adverse reactions.

Can Spedra cause unwanted erections?

Spedra is only effective under sexual stimulation, and unless the patient is at risk of priapism (spontaneous erection) due to other pathologies, it does not produce unwanted erections or erections that are not caused by sexual activity.

Can I split the Spedra tablet so as not to take it whole?

If you wish or need to reduce the dose of Spedra by half, the ideal is to purchase the existing presentation with the exact dosage.

It is not advisable to split the tablets of any medicine in half as the resulting dose is inaccurate and can be counterproductive.

Do I need a prescription to buy Spedra or can I get it without it?

Since it is advisable to consult a doctor before starting any treatment for erectile dysfunction, Spedra in pharmacy is usually sold only with a prescription. In some establishments and under new modalities, it may be possible to buy Spedra online without a prescription.

Is stone less expensive online than in the pharmacy?

To buy Spedra in a pharmacy, patients need a prescription, which adds to the cost of the medicine, there is also a medical consultation cost that can vary. With the ability to buy Spedra online and buy Spedra without a prescription, it may be less expensive than in in-person pharmacies.

What should I do if Spedra doesn’t work for me or becomes ineffective over time?

If with the passage of time Spedra ceases to function effectively or simply does not achieve the desired effect, you should consult your doctor, who will probably suggest increasing progressively until you reach the maximum and tolerable daily dose before studying other causes or considering treatment alternatives.

Never take more than the recommended maximum daily dose or take another erectile dysfunction medication (or another PDE5 inhibitor) at the same time. Serious adverse effects may occur.