Tadalafil (analogous to the generic compound Cialis) is a drug used to treat persistent erectile dysfunction in adult men, also indicated in other pathologies. Before starting to use it to improve your sexual performance find here information such as its presentation, form of administration and dosage, mechanism of action, warnings and precautions, adverse effects, price and everything you need to know before buying Tadalafil without prescription or buy Tadalafil cheap online.
About Tadalafil: Tadalafil is a drug used to treat Erectile Dysfunction (ED) in adult men.
What is it: It is one of the drugs in the group of phosphodiesterase 5 inhibitors (such as Levitra and Viagra), used for male sexual and urologic disorders.
It also has therapeutic indication for some cases of Pulmonary Hypertension.
Laboratory: Originally Tadalafil could only be found under the trade name Cialis by the laboratory Lilly ICOS, but currently several laboratories are licensed for distribution as generic in Spain, such as: Accord, Alter, Aristo, Aurovit, Cinfamed, Combix, Krka, Mabo, Mylan, Norbon, Pensa, Qualigen, Ratiopharm, Sandoz, Stada, Tarbis, Tecnigen, Teva.
Form of administration: Orally, with a glass of water, 30 to 60 minutes before initiating sexual activity, as needed by the patient.
How is it presented: Film-coated tablets of 5 mg, 10 mg, 20 mg and 40 mg in boxes containing from 10 to 360 tablets.
Price per tablet: The price per tablet to buy cheap Tadalafil may vary depending on the concentration and quantity of tablets in the box.
Tadalafil price of 5 mg: prices ranging from € 0.77 to € 2.95 per tablet, in boxes from 10 to 360 tablets.
Tadalafil price of 10 mg: prices ranging from € 1.10 to € 2.56 per tablet, in boxes from 10 to 360 tablets.
Tadalafil price of 20 mg: prices ranging from € 1.22 to € 2.91 per tablet, in boxes from 10 to 360 tablets.
Tadalafil price of 40 mg: prices ranging from € 1.97 to € 3.74 per tablet, in boxes from 10 to 90 tablets.
Initiation of action: It is recommended to take it 30 to 60 minutes before sexual activity, but cases of initiation of action have been reported as soon as 16 minutes after taking.
Duration of Action: Tadalafil outperforms all similar products, lasting up to 36 hours after ingestion.
Alteration with meals: Tadalafil can be ingested with or without food, however in some cases it has been shown that with copious or abundant meals may take a little longer to start its effect.
Side effects: Although usually well tolerated, some adverse effects that may occur with Tadalafil are: allergic reactions to the components of the formula, headache and migraine, syncope, chest pain and/or palpitations, blurred vision, facial redness, nasal congestion, hypotension, nosebleeds, nausea and/or vomiting, abdominal pain and discomfort including diarrhea in over 65 years, muscle aches in the back and extremities, rash, increased uterine bleeding in women, edema or swelling in the face and extremities.
How does Tadalafil act?
Tadalafil belongs to a group of drugs that inhibit phosphodiesterase 5 (PDE5), which degrade the Guanosine Cyclic Monophosphate (cGMP) of the penis. This (cGMP) relaxes the smooth muscle of the male sexual organ, increasing the arrival of blood and therefore, producing a satisfactory erection. With the inhibition of PDE5 that degrades it, the concentration of cGMP increases considerably and its function improves.
In addition to this mechanism of action on the penis, Tadalafil has other effects that have made it used over time for the treatment of urological pathologies such as Benign Prostatic Hyperplasia.
Why switch to Tadalafil?
Cheap Tadalafil has shown that for a much lower price (depending on the laboratory) to other brands, has the same effectiveness.
Although in terms of effectiveness and success rates Tadalafil shows similarity with its analogues, has a significant advantage that makes it a profitable and improved option: the duration of up to 36 hours in the body after ingestion.
In persistent Erectile Dysfunction (ED), it means that the patient can take it on demand or as needed with satisfactory sexual performance without the need to take it daily.
Instructions for use and dosage of Tadalafil
It is advisable to take Tadalafil oral tablet 30 to 60 minutes before sexual activity, but cases of satisfactory erection have been recorded as soon as 16 minutes after ingestion.
The initial recommended dose is the average presentation (as needed by the patient) of 10 mg, which may be reduced to 2.5 mg or 5 mg, or increased to 20 mg depending on its effectiveness and the tolerability of the patient.
Since its effect can last up to 36 hours in the patient’s body, its daily continuous use is not recommended, but the need of the patient when he will have sexual activity. It is important to emphasize that Tadalafil only works under sexual stimulation, and there will be no permanent or spontaneous erections without it after ingestion.
Is cheap Tadalafil effective every time?
Studies have shown that approximately 70% of patients prefer Tadalafil over other drugs to treat erectile dysfunction, and this has to do with its high effectiveness and successful penetration rates.
Undesirable effects that could occur with the taking of Tadalafil
Some infrequent side effects, but that have occurred with the taking of Tadalafil, are:
- Reactions of hypersensitivity or allergy to the components of the formula.
- Headache, migraine or blurred vision.
- Chest pain, fatigue, hypotension or palpitations.
- Nasal congestion and/or nosebleeds.
- Dyspepsia, abdominal pain, nausea, vomiting, gastroesophageal reflux, diarrhea in over 65 years.
- Rash or rash, as well as facial redness.
- Muscle, back or limb aches.
- Uterine bleeding in women.
- Facial or limb edema.
Contraindications: In what cases should not take Tadalafil?
- Allergy or hypersensitivity to any of the components of the formula.
- History of cardiovascular disease such as clinically significant aortic and mitral valve disease, pericardial constriction, restrictive or constrictive cardiomyopathy, disorders of the left ventricle, arrhythmias, coronary heart disease with symptoms, uncontrolled arterial hypertension.
- Myocardial infarction in the 90 days prior to taking.
- Patients under treatment with nitrates or nitric oxide donors.
- Hypotension, or blood pressure less than 90/50 mmHg.
- Unstable angina or angina triggered by sexual activity.
Patients who have lost vision due to non-arteritic anterior ischemic optic neuropathy, regardless of whether or not it was caused by another PDE5 inhibitor; or patients at risk of visual impairment or retinitis pigmentosa.
- Concomitant use with alpha-blockers (such as doxazosin).
- Joint use with other PDE 5 inhibitors, or any other treatment for erectile dysfunction.
- Heart failure class II or higher or Stroke in the 6 months prior to taking.
- Concomitant use with CYP3A4 inducers (such as rifampicin) or inhibitors (ketoconazole, ritonavir),
Severe liver or kidney failure.
- History that may predispose to persistent erection (priapism) such as sickle cell anemia, multiple myeloma, or leukemia.
- Anatomical deformities of the penis (such as angulation, cavernous fibrosis, Peyronie’s disease).
Concomitant use with Riociguat (a medication to treat pulmonary hypertension) as it can potentially produce symptomatic hypotension.
- Use in patients under 18 years of age.
Interactions of Tadalafil in taking with other substances:
Other drugs can increase or decrease plasma concentrations of Tadalafil if used together, increasing or decreasing its effect, and even enhancing adverse reactions. These medications are: nitrates; alpha-blockers or other medications to treat high blood pressure; riociguat; anticonvulsant medications such as phenytoin, carbamazepine, and phenobarbital; antimicrobials such as rifampicin, clarithromycin, erythromycin, and itraconazole; 5-alpha-reductase inhibitors; and any other medication for erectile dysfunction or other PDE5 inhibitor.
Fertility, Pregnancy and Breastfeeding
In some dog studies a reduction in sperm production was seen. However, Tadalafil is unlikely to affect fertility.
Since Tadalafil is also used in some cases of Pulmonary Hypertension, women occasionally use it. Its safety data on pregnant women are scarce, so it is recommended to avoid its use during pregnancy.
It should not be used during breastfeeding, as it has been shown excretion of Tadalafil by breast milk.
In case of overdose, take regular supportive measures and call the poison hotline immediately. Up to 500 mg were administered during studies to healthy individuals without serious adverse reactions.
FAQ (Frequently Asked Questions):
Why should patients consult their doctor before taking medication for the first time to treat erectile dysfunction?
All medications have specific therapeutic indications, as well as warnings and adverse effects that the physician can compare with each patient’s medical history and history. This is how it is determined if it is suitable for a particular treatment for erectile dysfunction.
In the case of Tadalafil, this also has other uses and interactions, as well as a longer duration of effect than other inhibitors of phosphaesterase 5, so it is the doctor who should prescribe it and explain in detail its form of administration, dosage and risks.
What is the difference between Tadalafil and Viagra?
Despite belonging to the same group of drugs called PDE5 inhibitors, cheap Tadalafil and Viagra (Sildenafil) differ in the name of its active ingredient, and in the duration of its effect: Viagra lasts from 4 to 6 hours, while Tadalafil can reach up to 36 hours of effect with a single dose, making many patients prefer it and want to continue to improve their sexual confidence.
In addition to this, Tadalafil was shown to be better tolerated and to have fewer adverse effects in some comparative studies with Viagra.
Is Tadalafil stronger than Viagra?
In terms of efficacy and successful penetration rates, Tadalafil and Viagra proved to be quite similar, so it cannot be said that one is stronger than the other. However, there is a marked difference in the duration of action time: 36 hours for Tadalafil, and 6 hours for Viagra, making the former more potent in terms of time effect.
What is the recommended dose to start taking Tadalafil?
The initial recommended dose of cheap Tadalafil is its average presentation of 10 mg, but this can be decreased to 2.5 mg or 5 mg or increased to 20 mg depending on whether the desired effect was achieved and as tolerated by the patient.
Is there a generic for Tadalafil?
In general, Tadalafil is presented for sale as the generic of its active ingredient by several laboratories, but the compound is the same as the trademarks for a lower price.
Why does the price vary so much?
Laboratories adjust average prices to sell cheap Tadalafil to pharmacies, and it is the pharmacists who decide the retail price. In addition, the price to buy Tadalafil online and buy Tadalafil at the pharmacy can fluctuate by several factors, including the need for a prescription.
How long does the effect of Tadalafil last and how often can I take it?
Tadalafil can have a duration of action of up to 36 hours on the body. Its daily intake is not recommended, but to the patient’s need and tolerability.
However, and always under medical supervision and prescription, some patients with persistent Erectile Dysfunction have benefited from daily intake of Tadalafil 5 mg, according to studies. Consult your doctor to determine the dosage depending on your case.
Can I drink alcohol if I took a Tadalafil?
No alteration has been shown in the concentrations of alcohol and Tadalafil when taken together. However, alcohol alone can affect and impair sexual performance.
Can I take Tadalafil with other medications?
Tadalafil interacts with several medications, it is always advisable to consult the interactions and the doctor before starting to take it.
Tadalafil should not be used concomitantly with other treatments for Erectile Dysfunction (ED).
Can Tadalafil produce unwanted erections?
Priapism is rare with taking Tadalafil, and sexual stimulation is necessary for an erection to appear after ingestion.
Can I split the Tadalafil to not take the whole tablet?
It is not recommended to split the tablets coated with Tadalafil because the resulting dose may be inaccurate. However, consult your doctor if you wish to do so for any intake.
Do I need a prescription to get Tadalafil or can I buy it without it?
To buy Tadalafil in pharmacy is usually asked for a prescription, since it is indicated that a doctor authorizes its use in adult men. To buy Tadalafil online, it is possible that depending on the establishment you can buy Tadalafil without a prescription.
Is Tadalafil less expensive online than in presential pharmacies?
To buy Tadalafil online, you might be able to buy Tadalafil without a prescription and this will save you the paid doctor’s visit. Therefore, it is possible that buying Tadalafil online is cheaper than buying Tadalafil at a pharmacy.
However, it is important to make sure that it is a safe and authorized site for the sale of Tadalafil.
What should I do if Tadalafil doesn’t work for me or becomes ineffective over time?
If Tadalafil does not work or stops working, the ideal is to gradually increase to the maximum presentation every 36 hours, under medical supervision. If this is ineffective in achieving a satisfactory erection, consult your doctor for other treatment options.
Never exceed the maximum daily dose or take another treatment for Erectile Dysfunction simultaneously. This could trigger serious adverse reactions.